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Hydrocodone and acetaminophen combination is used to relieve pain severe enough to require opioid treatment and when other pain medicines did not work well enough or cannot be tolerated

Hydrocodone is an opioid pain drug that helps treat moderate pain. To treat severe pain, you can use the extended-release form of Hydrocodone because they are beneficial for the around-the-clock treatment of severe pain. Two of the available drugs as extended-release forms of Hydrocodone are Zohydro ER and Hysingla ER. extended-release forms are not for use on an as-needed basis.