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Ambien is a brand name for a medication called zolpidem, which is used to treat insomnia and other sleep problems. Ambien belongs to a class of drugs called nonbenzodiazepines or Z-drugs, which act on the same receptors in the brain as benzodiazepines, but with different chemical structures. Ambien works by increasing the activity of a neurotransmitter called GABA, which inhibits the activity of other neurons and helps induce sleep. Ambien is usually taken by mouth as a tablet, but it can also be taken sublingually (under the tongue), as an oral spray, or rectally.