In 2026, modafinil stands out as a unique "atypical" stimulant because it promotes wakefulness without the aggressive physiological "push" associated with traditional amphetamines. Unlike older stimulants that flood the entire central nervous system with norepinephrine, modafinil acts more selectively as a eugeroic, focusing its activity on brain regions like the hypothalamus to stimulate the orexin and histamine systems.
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