Tramadol Vs Morphine

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Tramadol and morphine are both opioid analgesics used to treat moderate to severe pain, but they differ in strength, mechanism, and risk profiles. Morphine is a strong, traditional opioid that acts directly on opioid receptors, providing powerful pain relief but with a higher risk of addiction, respiratory depression, and sedation. Tramadol is a weaker synthetic opioid that not only affects opioid receptors but also inhibits serotonin and norepinephrine reuptake, offering milder pain control. Tramadol generally has fewer side effects but may cause seizures or serotonin syndrome, especially when combined with other medications. Morphine is preferred for severe pain; tramadol suits milder cases.