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Hydrocodone 10-650 mg, commonly known as the M361 blue pill, is a potent combination of 10 mg hydrocodone and 650 mg acetaminophen. This medication is designed to provide effective relief from moderate to severe pain by altering the brain's response to pain signals. The hydrocodone component acts on the mu-opioid receptors, while acetaminophen helps reduce fever and enhances pain relief. Typically, the effects begin within 10–15 minutes and can last up to 4 hours.