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Vicodin is a prescription opioid pain medication that is used to treat moderate to severe pain. It is a combination of hydrocodone and acetaminophen. Hydrocodone is an opioid agonist, which means that it binds to opioid receptors in the brain and spinal cord to reduce pain signals. Acetaminophen is a non-opioid pain reliever that works by inhibiting the production of prostaglandins, which are chemicals that cause pain and inflammation.