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Oxycodone is used to relieve pain severe enough to require opioid treatment, and when other pain medicines do not work well enough or cannot be tolerated. oxycodone is a powerful drug, so it may make it difficult for you to drive or operate heavy machinery. Oxycodone side effects often subside over time as the body adjusts, with the notable exception of constipation, which is likely to persist throughout the duration of use. Oxycodone pills are prescription opioid analgesics used for moderate to severe pain.