Are Oxycodone and Gabapentin Safe When Used at the Same Time?

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Oxycodone and gabapentin are both commonly prescribed medications, but they serve very different purposes. Oxycodone is an opioid painkiller often used for moderate to severe pain, while gabapentin is primarily prescribed for nerve pain, seizures, or certain types of anxiety. While each medication can be effective on its own, taking them together requires caution. Combining oxycodone and gabapentin can increase the risk of side effects such as drowsiness, dizziness, confusion, difficulty breathing, and even life-threatening respiratory depression in severe cases.